6533b826fe1ef96bd1283bd3

RESEARCH PRODUCT

ChemInform Abstract: Polycondensed Nitrogen Heterocycles. Part 23. Pyrrolo(3,2-c)cinnolines by a Japp-Klingemann-Type Reaction.

Girolamo CirrincioneGaetano DattoloAnna Maria AlmericoEnrico Aiello

subject

chemistry.chemical_compoundchemistryIntramolecular forceChlorinechemistry.chemical_elementExtrusionGeneral MedicineNitrogenMedicinal chemistryCinnolineIonPyrrole

description

Pyrrolo[3,2-c]cinnoline derivatives were obtained by an unusual Japp-Klingemann reaction involving an intramolecular azadehalogenation on the pyrrole nucleus. Such an azadehalogenation represents the first example of Japp-Klingemann reaction in which the extrusion of positive chlorine ion is verified.

https://doi.org/10.1002/chin.199047149