6533b826fe1ef96bd1284516
RESEARCH PRODUCT
ChemInform Abstract: Two New Sesquiterpene Derivatives from the Tunisian Endemic Ferula tunetana Pom.
Jean-françois MirjoletMarie-aleth Lacaille-duboisZine MighriHichem Ben JannetFethia Harzallah-skhiriAymen JabraneAymen JabraneOlivier Duchampsubject
Terpenechemistry.chemical_compoundStigmasterolchemistryPropiophenoneStereochemistryFerula tunetanaGeneral MedicineSesquiterpeneCytotoxicityCoumarinUmbelliprenindescription
A new sesquiterpene ester, tunetanin A (1), a new sesquiterpene coumarin, tunetacoumarin A (2), together with eight known compounds, i.e., coladin (3), coladonin (4), isosmarcandin (5), 13-hydroxyfeselol (6), umbelliprenin (7) propiophenone (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D- and 2D-NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1-7 towards two human colon cancer cell lines, HT-29 and HCT 116, was evaluated. Compounds 3, 4, and 6 showed weak cytotoxic activities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-15 | ChemInform |