6533b826fe1ef96bd1284548
RESEARCH PRODUCT
Synthetic Inhibitors of Cell Adhesion: A Glycopeptide from E-Selectin Ligand 1 (ESL-1) with the Arabino Sialyl Lewisx Structure
Horst KunzHolger HerznerMartin K. WildMarkus RöschDietmar VestweberWolfgang Dippoldsubject
carbohydrates (lipids)Solid-phase synthesisBiochemistryChemistryembryonic structuresGeneral ChemistryE-selectin ligand-1Cell adhesionLigand (biochemistry)CatalysisGlycopeptidedescription
Particularly selective methods are required for the synthesis of arabino sialyl Lewisx glycopeptides owing to the acid-labile β-arabinopyranoside bond. It is important for the inhibition of cell adhesion that the arabino sialyl Lewisx glycopeptide 1, which contains the Gly 672 -Asp 681 sequence of the E-selectin Ligand 1 (ESL-1), binds ten times more strongly than sialyl Lewisx to E-selectin, although it is monovalent and does not contain L-fucose, which is considered essential.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-10-15 | Angewandte Chemie International Edition |