Mycobacterium tuberculosis rezistences pret antibakteriālajiem līdzekļiem noteikšana ar bactec mgit sistēmu

6533b826fe1ef96bd1284b81

RESEARCH PRODUCT

Mycobacterium tuberculosis rezistences pret antibakteriālajiem līdzekļiem noteikšana ar bactec mgit sistēmu

Jūlija Voicehovska

subject

M.tuberculosis Tuberkuloze Farmācija BACTEC MGIT Antibakteriālā rezistence

description

Mūsdienās tuberkuloze ir viena no biežākajiem pacientu nāves cēloņiem pasaulē. Tuberkulozi vairākumā gadījumu izraisa M.tuberculosis. Bakalaura darbā tika analizēta literatūra, lai saprastu M.tuberculosis rezistences mehānismus pret prettuberkulozes līdzekļiem. Praktiskajai daļai tika izmantota BACTEC MGIT sistēma M.tuberculosis rezistences noteikšanai, un arī tika izmantoti rezultāti, kas iegūti SIA „RAKUS” Tuberkulozes un plaušu slimību centra Mikobakterioloģijas laboratorijā un apkopoti laboratorijas informācijas sistēmā (LIS). Satistikas analīze liecina par to, ka pasaulē un Latvijā tuberkulozes gadījumu skaits samazinās un, pateicoties labām ārstēšanas stratēģijām, izārstēto cilvēku skaits ir augsts, salīdzinot ar citām Eiropas valstīm. Starp visiem rezistentiem gadījumiem visbiežāk rezistence bija pret izoniazīdu un rifampicīnu no 1.rindas medikamentiem un no 2. rindas vairāk rezistento M.tuberculosis bija pret ofloksacīnu. Pret linezolīdu netika atrasts neviens rezistents M.tuberculosis izolāts.

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/35817

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