6533b826fe1ef96bd1284f3f
RESEARCH PRODUCT
ChemInform Abstract: Synthesis of New 2-(((Phenoxy or Phenyl)acetyl)amino)benzoic Acid Derivatives as 3α-Hydroxysteroid Dehydrogenase Inhibitors and Potential Antiinflammatory Agents.
Giuseppe DaidoneSalvatore PlesciaDomenico SchillaciM. L. Bajardisubject
Steric effectschemistry.chemical_compoundchemistryIn vivoAcetyl chlorideYield (chemistry)Anthranilic acidDehydrogenaseGeneral MedicineMedicinal chemistryIn vitroBenzoic aciddescription
A number of 2-([(phenoxy or phenyl)acetyl]amino)benzoic acid derivatives were prepared in about 50% yield from (phenoxy or phenyl)acetyl chloride and anthranilic acid derivatives. All the compounds were tested as in vitro inhibitors of 3 alpha-hydroxysteroid dehydrogenase, since enzyme inhibition predicts potential antiinflammatory activity in vivo. The most active compounds 3 l, m, s are about 3.5 times more active than acetylsalicylic acid (ASA). Activity is influenced by electronic as well as steric effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-12 | ChemInform |