6533b826fe1ef96bd1285114

RESEARCH PRODUCT

Minireview: pH and synaptic transmission

Christian A. HübnerAnne SinningAnne Sinning

subject

BiophysicsNeurotransmissionBiochemistryMouse modelGABAStructural BiologySynaptic augmentationGeneticsAnimalsHumansPremovement neuronal activitySynaptic transmissionMolecular BiologyNeuronal excitabilityCarbonic AnhydrasesAcid-Base EquilibriumMembrane potentialCarbonic anhydraseVoltage-dependent calcium channelChemistryGlutamate receptorCell BiologyBicarbonatesSynaptic fatigueBiochemistrypH regulationSynapsesSynaptic plasticityBiophysicsIon transporter

description

AbstractAs a general rule a rise in pH increases neuronal activity, whereas it is dampened by a fall of pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic acid equivalents. Moreover, the negative membrane potential of neurons promotes the intracellular accumulation of protons. Synaptic key players such as glutamate receptors or voltage-gated calcium channels show strong pH dependence and effects of pH gradients on synaptic processes are well known. However, the processes and mechanisms that allow controlling the pH in synaptic structures and how these mechanisms contribute to normal synaptic function are only beginning to be resolved.

yearjournalcountryeditionlanguage
2013-05-10FEBS Letters
10.1016/j.febslet.2013.04.045http://dx.doi.org/10.1016/j.febslet.2013.04.045