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RESEARCH PRODUCT
Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
Kimberly YoungMichael E. HasselmoHolger Dannenbergsubject
0301 basic medicinevolume transmissioncholinergic fibersCognitive NeuroscienceNeuroscience (miscellaneous)ReviewHippocampal formationReceptors NicotinicCholinergic modulationHippocampuslcsh:RC321-571tonic depolarization03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineNeuromodulationMuscarinic acetylcholine receptorNeural PathwaysmedicineAnimalsHumanslcsh:Neurosciences. Biological psychiatry. NeuropsychiatryCholinergic FibersNicotinic ReceptorsChemistrypresynaptic inhibitionReceptors MuscarinicacetylcholineSensory Systems030104 developmental biologymedicine.anatomical_structureCholinergicNeuroscience030217 neurology & neurosurgeryAcetylcholinemedicine.drugNeurosciencedescription
This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarinic and nicotinic receptors and the heterogeneity of effects on different subclasses of neurons.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-12-13 | Frontiers in Neural Circuits |