6533b826fe1ef96bd1285348

RESEARCH PRODUCT

Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy

Melania Lo IaconoChiara ModicaGaetana PorcelliOrnella Roberta BrancatoGiampaolo MuratorePaola BiancaMiriam GaggianesiAlice TurdoVeronica VeschiMatilde TodaroSimone Di FrancoGiorgio Stassi

subject

cancer stem cellstarget therapySettore MED/50 - Scienze Tecniche Mediche ApplicateexosomesBiochemistryadipose tissueNeoplasmsAdipocytesNeoplastic Stem CellsHumanstumor microenvironmentSettore MED/46 - Scienze Tecniche Di Medicina Di LaboratorioMolecular Biologyadipokines

description

The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirectional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.

yearjournalcountryeditionlanguage
2022-05-14
10.3390/biom12050702http://hdl.handle.net/10447/557957