Mildronāta, piracetama un D3-72 ietekme uz atmiņas procesiem aktīvās izvairīšanās testā zemas, vidējas un augstas aktivitātes žurkām

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RESEARCH PRODUCT

Mildronāta, piracetama un D3-72 ietekme uz atmiņas procesiem aktīvās izvairīšanās testā zemas, vidējas un augstas aktivitātes žurkām

Reinis ŠVarcbahs

subject

description

Aktīvās izvairīšanās eksperiments (CAR) ļauj pētīt jaunu vielu ietekmi uz atmiņas procesiem un mācīšanos. Iepriekšējos pētījumos jaunsintezēts 1,4-dihidropiridīnu klases savienojums – D3-72, piracetams un mildronāts uzrādīja atmiņu uzlabojošus rezultātus pasīvās izvairīšanās testā (PAR). Šajā pētījumā, izmantojot CAR testu uz žurkām, kas sagrupētas dažādās izpētes aktivitātes grupās (zema, vidēja, augsta), noteicu, vai minētajām vielām ir ietekme uz nosacījumu un beznosacījuma atbilžu veidošanos. Iegūtie rezultāti norāda, ka neviena no attiecīgajām vielām CAR testā neuzrāda atmiņu uzlabojošus rezultātus, arī žurku izpētes aktivitātes atšķirības nekorelē ar CAR rezultātiem. Šajā eksperimentā vielas nespēja uzlabot atmiņu visdrīzākais tādēļ, ka tika izmantotas jaunas, pieaugušas žurkas. Turpmāk vajadzētu izmantot vecus vai amnēzijas-modeļ dzīvniekus.

year	journal	country	edition	language
2011-01-01

https://dspace.lu.lv/dspace/handle/7/26391

PEPhysical Sciences and Engineering
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