No Dracocephalum ruyschiana L. iegūtu bioloģiski aktīvo vielu ādu balinošo īpašību novērtējums in vitro

6533b827fe1ef96bd12855d7

RESEARCH PRODUCT

No Dracocephalum ruyschiana L. iegūtu bioloģiski aktīvo vielu ādu balinošo īpašību novērtējums in vitro

subject

tirozināze in vitro testēšana ādu balinošā kosmētika Ruiša pūķgalve augu in vitro kultūras Bioloģija

description

Darba mērķis bija novērtēt no Ruiša pūķgalves savvaļas augiem un in vitro dzinumu kultūrām iegūtu bioloģiski aktīvos savienojumus saturošu ekstraktu ādu balinošās īpašības, izmantojot in vitro testēšanas metodes. Ruiša pūķgalves in vitro ekstrakta drošība tā pielietojumam kosmētikas preparātos tika noteikta, pārbaudot tā ietekmi uz dažādu ādas tipu šūnu proliferāciju un morfoloģiju. Ādu balinošā potenciāla novērtēšanai tika izmantots sēņu tirozināzes inhibīcijas tests un cilvēka ādas melanomas šūnu in vitro modelis. No Ruiša pūķgalves in vitro dzinumu kultūras tika iegūts savvaļas augam līdzvērtīgs un lietošanai drošs ekstrakts, kas inhibēja sēņu un šūnu tirozināzes aktivitāti, bet būtisiki neietekmēja melanīna koncentrāciju un pigmentācijas gēnu ekspresiju melanomas šūnās, kas liecina par ekstrakta specifisku ietekmi uz tirozināzes enzimātisko aktivitāti.

year	journal	country	edition	language
2016-01-01

https://dspace.lu.lv/dspace/handle/7/32195

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