Role of Smads in respiratory disease pathogenesis

6533b827fe1ef96bd128563c

RESEARCH PRODUCT

Role of Smads in respiratory disease pathogenesis

Francesca Magno Simona Corrao Tiziana Loria Melania Lo Iacono

subject

Settore BIO/16 - Anatomia Umana TGF-beta1 COPD Smads Lung disease

description

Transforming Growth Factor beta (TGFβ) cytokine plays an important role in normal pulmonary morphogenesis and function as well as in the pathogenesis of lung diseases. The principal signaling pathway downstream to activate TGFβ is the Smad pathway. Even though many studies have focused on Smads’ structural features and pathway, less is known about the possible relationship between protein and mRNA expression of Smads and lung diseases. This review will focus on Smads and sum up what is know about their role in some respiratory diseases: COPD,asthma end fibrosis

year	journal	country	edition	language
2008-01-01

http://hdl.handle.net/10447/41257

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