6533b827fe1ef96bd1285979
RESEARCH PRODUCT
A l-glutamate-responsive delivery system based on enzyme-controlled self-immolative arylboronate-gated nanoparticles
Pablo GaviñaPablo GaviñaReynaldo VillalongaAlba García-fernándezTania M. Godoy-reyesFélix SancenónAna M. CosteroAna M. CosteroRamón Martínez-máñezAntoni Llopis-lorentesubject
chemistry.chemical_classificationEnzymechemistry010405 organic chemistryL glutamateOrganic ChemistryNanoparticleDelivery system010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical sciencesdescription
We report herein a L-glutamate (L-Glu)-responsive delivery system. It consists of Janus Au–mesoporous silica (MS) nanoparticles functionalized with L-glutamate oxidase on the Au face and with self-immolative arylboronate derivatives as caps on the MS face. The MS face is additionally loaded with a cargo. The delivery paradigm is based on the recognition of L-Glu by the enzyme and the subsequent formation of H2O2, which induces the cleavage of the self-immolative gate and the uncapping of the pores. Given the importance of L-Glu as a key neurotransmitter, we hope that these findings will help in designing new therapeutic strategies for nervous system diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | Organic Chemistry Frontiers |