6533b827fe1ef96bd12859e0

RESEARCH PRODUCT

Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue

Ulrich FörstermannHuige LiNing Xia

subject

0301 basic medicinemedicine.medical_specialtyEndotheliumAdipose tissue030204 cardiovascular system & hematologyResveratrolGeneral Biochemistry Genetics and Molecular BiologyNitric oxide03 medical and health scienceschemistry.chemical_compound0302 clinical medicineHistory and Philosophy of ScienceEnosInternal medicineAntithromboticmedicinebiologyChemistryGeneral NeuroscienceNitric Oxide Synthase Type IIIbiology.organism_classificationNitric oxide synthase030104 developmental biologyEndocrinologymedicine.anatomical_structurebiology.protein

description

Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). Experiments using gene-disrupted mice have demonstrated that eNOS has antihypertensive, antithrombotic, and antiatherosclerotic effects. Recent studies show that eNOS is expressed not only in the endothelium but also in the perivascular adipose tissue (PVAT). Resveratrol prevents eNOS uncoupling and upregulates eNOS expression and activity. These effects of resveratrol are well established for the eNOS enzyme in the endothelium. Interestingly, resveratrol also improves PVAT function. However, a causal role for eNOS in the effects of resveratrol on PVAT function has not yet been verified and needs to be studied in the future.

yearjournalcountryeditionlanguage
2017-07-03Annals of the New York Academy of Sciences
https://doi.org/10.1111/nyas.13397