6533b827fe1ef96bd1286137
RESEARCH PRODUCT
Ciprofloxacin Polymers Derived from Diallyltin and Divinyltin Dihalides
Zhao AShahic K. RRonerc M. RBarot GTiziana FioreClaudia PelleritoMichelangelo ScopellitiLorenzo PelleritoCarraher C. E. Jrsubject
Settore CHIM/03 - Chimica Generale E InorganicaCiprofloxacin organotin organotin polymers diallyltin divinyltin F-MALDI MS organotin polyamine esters MALDI mass spectroscopy infrared spectroscopy colon cancerbone cancer prostate cancer pancreatic cancerdescription
The initial synthesis of condensation polymers from newly available divinyltin dichloride and diallyltin dichloride and ciprofloxacin is accomplished employing a modified interfacial polycondensation process. The polymeric (DP are about 2,000) products are rapidly (less than 15 seconds) formed in good yield. Infrared spectroscopy shows the formation of Sn-O and Sn-N bonds as predicted from the proposed structure. F-MALDI MS also shows ion fragments containing organotin in the predicted isotopic abundances as well as ion fragments containing both organotin and ciprofloxacin. The polymers exhibit low toxicity towards healthy WI-38 cells with variable toxicities towards a variety of cancer cell lines.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-01-01 |