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RESEARCH PRODUCT

13C-Decoupled J-Coupling Spectroscopy Using Two-Dimensional Nuclear Magnetic Resonance at Zero-Field

Dmitry BudkerDmitry BudkerDmitry BudkerArne KentnerArne KentnerMichael C. D. TaylerMichael C. D. TaylerTobias F. SjolanderAlexander PinesAlexander Pines

subject

ChemistryCarbon-13 NMR satelliteRelaxation (NMR)Carbon-13 NMR010402 general chemistryJ-coupling01 natural sciences0104 chemical sciencesFree induction decayNuclear magnetic resonance0103 physical sciencesSpin echoGeneral Materials SciencePhysical and Theoretical Chemistry010306 general physicsTwo-dimensional nuclear magnetic resonance spectroscopyEarth's field NMR

description

We present a two-dimensional method for obtaining 13C-decoupled, 1H-coupled nuclear magnetic resonance (NMR) spectra in zero magnetic field using coherent spin-decoupling. The result is a spectrum determined only by the proton–proton J-coupling network. Detection of NMR signals in zero magnetic field requires at least two different nuclear spin species, but the proton J-spectrum is independent of isotopomer, thus potentially simplifying spectra and thereby improving the analytical capabilities of zero-field NMR. The protocol does not rely on a difference in Larmor frequency between the coupled nuclei, allowing for the direct determination of J-coupling constants between chemically equivalent spins. We obtain the 13C-decoupled zero-field spectrum of [1–13C]-propionic acid and identify conserved quantum numbers governing the appearance of cross peaks in the two-dimensional spectrum.

yearjournalcountryeditionlanguage
2017-03-21The Journal of Physical Chemistry Letters
https://doi.org/10.1021/acs.jpclett.7b00349