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RESEARCH PRODUCT
Variations in Substitution Rate in Human and Mouse Genomes
H. H. Von GrünbergMarkus KollmannMarkus KollmannJens TimmerMartin Peifersubject
Genomics (q-bio.GN)GenomeModels GeneticGenome HumanRelative standard deviationSubstitution (logic)AutocorrelationPopulations and Evolution (q-bio.PE)Genetic VariationGeneral Physics and AstronomyGenomicsTime resolutionBiologyQuantitative Biology::GenomicsGenomeMiceEvolutionary biologyFOS: Biological sciencesAnimalsHumansQuantitative Biology - GenomicsHuman genomeQuantitative Biology - Populations and EvolutionRepetitive Sequences Nucleic Aciddescription
We present a method to quantify spatial fluctuations of the substitution rate on different length scales throughout genomes of eukaryotes. The fluctuations on large length scales are found to be predominantly a consequence of a coarse-graining effect of fluctuations on shorter length scales. This is verified for both the mouse and the human genome. We also found that both species show similar standard deviation of fluctuations even though their mean substitution rate differs by a factor of two. Our method furthermore allows to determine time-resolved substitution rate maps from which we can compute auto-correlation functions in order to quantify how fast the spatial fluctuations in substitution rate change in time.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-12-18 |