Virulences potenciāla izpēte veselo cilvēku Staphylococcus epidermidis komensālos celmos

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RESEARCH PRODUCT

Virulences potenciāla izpēte veselo cilvēku Staphylococcus epidermidis komensālos celmos

Anna Gorbatjuka

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Mūsdienās Staphyloccocus epidermidis ir kļuvis par visbiežāk izolēto nozokomiālo infekciju izraisītāju. Pamatojoties uz iepriekšējiem pētījumiem, ar biofilmas veidošanu saistītie icaA un aap gēni parasti ir konstatējami nozokomiālos izolātos, tādēļ tie varētu tikt izmantoti kā virulences marķieri, lai diferencētu komensālos S. epidermidis izolātus no invazīviem. Maģistra darba mērķis ir izpētīt S. epidermidis virulences faktoru - icaA un aap gēnu klātbūtni un to klīnisko nozīmi komensālos celmos. Iegūtie rezultāti liecina, ka statistiski ticami biežāk (p<0.02) abi icaA/aap gēni ir sastopami invazīvos celmos (42.86%) nekā komensālos celmos (26.67%). Abu gēnu vienlaicīga noteikšana var kalpot par virulences potenciāla marķieri komensālajos S. epidermidis celmos. Atslēgvārdi: Staphylococcus epidermidis, biofilma, virulences faktori

year	journal	country	edition	language
2012-01-01

https://dspace.lu.lv/dspace/handle/7/22370

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