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RESEARCH PRODUCT

Thyroid hormone deficiency disrupts rat eye neurodevelopment

Pedro Sanz SolanaVicente Vila BouSheila Pons-vazquezRoberto Gallego-pinazoCarmen EstradaVicente Zanon-morenoMaria D Pinazo-duran

subject

MaleThyroid Hormonesmedicine.medical_specialtygenetic structuresRat modelRetinachemistry.chemical_compoundHypothyroidismMicroscopy Electron TransmissionPregnancyInternal medicinemedicineAnimalsRats WistarMolecular BiologyRetinaGeneral NeuroscienceThyroidAge FactorsImidazolesOptic NerveRetinalOrgan SizeEmbryo Mammalianeye diseasesRatsDisease Models AnimalEndocrinologymedicine.anatomical_structureAnimals NewbornchemistryThyroid hormonesOptic nerveEye disorderFemalesense organsNeurology (clinical)PsychologyDevelopmental BiologyHormone

description

Clinical and experimental studies have highlighted the role played by thyroid hormones (TH) in neural and neuro-sensorial development. However, knowledge on TH mechanisms on the developing visual system is still incomplete. To uncover TH actions on the eyes and vision we carried out a microscopical study on the role of TH in the developing retina and optic nerve, in a rat model of controlled TH deficiency (THD). Morphometric and stereological analyses of the retina and optic nerve showed a reduction in the volume of the eye (p<0.001) and optic nerve cross-sectional area (p<0.001), and thinning of the retinal layers (p<0.001). Glial development and myelination was significantly delayed in the THD optic nerves (p<0.001), as compared to controls. The data indicate that TH play an essential role in neuro-retinogenesis. Substitutive TH therapy in critical periods, should be considered in hypothyroidism-related eye disorders as well as neurodegenerative retinal processes.

yearjournalcountryeditionlanguage
2010-11-26Brain Research
https://doi.org/10.1016/j.brainres.2011.04.005