Vaccinium ģints ogu spiedpalieku ekstraktu ietekme uz elastāzes, kolagenāzes un hialuronidāzes aktivitāti in vitro

6533b827fe1ef96bd1287404

RESEARCH PRODUCT

Vaccinium ģints ogu spiedpalieku ekstraktu ietekme uz elastāzes, kolagenāzes un hialuronidāzes aktivitāti in vitro

subject

kolagenāze Vaccinium spp. ogu ekstrakti elastāze hialuronidāze Farmācija spektrofotometrija

description

Demogrāfiskā novecošana šobrīd ir aktuāls jautājums visā pasaulē. Viena no novecošanas izpausmēm ir kolagēna, elastīna un hialuronskābes samazinājums, kuru izraisa pastiprināta enzīmu kolagenāzes, elastāzes un hialuronidāzes darbība. Ir atklāts, ka augu polifenoliem piemīt spēja inhibēt šo enzīmu darbību, kas ļauj tos ieteikt kā skrimšļa un ādas audu aizsarglīdzekļus. Pētījuma mērķis bija noteikt piecu Vaccinium ģints ogu spiedpalieku ekstraktu ietekmi uz elastāzes, kolagenāzes un hialuronidāzes aktivitāti in vitro testos. Iegūtie rezultāti liecina, ka visi pieci ogu spiedpalieku ekstrakti izraisa šo enzīmu inhibīciju. Krūmmelleņu, purva dzērveņu un brūkleņu spiedpalieku ekstrakti jau koncentrācijā 0,5 mg/ml uzrādīja 100% hialuronidāzes inhibīciju, bet kolagenāzes testos ekstraktu koncentrācijā 1 mg/ml maksimālā inhibīcija sasniedza 30%.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48692

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