6533b827fe1ef96bd12874a6
RESEARCH PRODUCT
Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.
Games Collaborative GroupM BanD BoothR HeardG StewartA GorisK VandenbroeckB DuboisM LaaksonenJ IlonenM AlizadehG EdanMc BabronD BrassatM ClanetI Cournu RebeixB FontaineG SemanaR GoeddeJ EpplenA WeberC Infante DuarteF ZippC RajdaK BencsikL VécseiS HeggartyC GrahamS HawkinsM LiguoriP Momigliano RichiardiD CaputoLm GrimaldiM LeoneL MassacesiC MilaneseM SalvettiM TrojanoB BieleckiMp MyckoK SelmajM SantosP MacielC PereiraA SilvaBm SilvaF CoradduMg MarrosuE AkessonJ HillertP DattaA OturaiHf HarboA SpurklandR GoertschesP VillosladaM EraksoyA HensiekA CompstonE SetakisJ GrayTw YeoS. SawcerGiovanni Savettierisubject
Multiple sclerosisGenome screenLinkage disequilibriumMeta-analysiSettore MED/26 - NeurologiaJAG1POU2AF1description
By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompatibility Complex (MHC) and are in LD with HLA-DRB1. Individual genotyping of the 12 non-MHC markers confirmed association for three of them — D11S1986, D19S552 and D20S894. Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 |