6533b828fe1ef96bd12877a1
RESEARCH PRODUCT
Dopamine antagonists impair ‘red-green’ discrimination in goldfish after intravitreal injection
Christa NeumeyerCarlos Mora-ferrersubject
SCH-23390genetic structuresChemistryMesopic visionColor visionStereochemistryTrichromacyDopamine antagonistchemistry.chemical_compoundDopaminemedicineHaloperidolBiophysicssense organsReceptormedicine.drugdescription
Color vision in goldfish is tetrachromatic. However, under mesopic illumination conditions the L-cones do not contribute to wavelength discrimination, and color vision becomes trichromatic. To investigate the role of dopamine in light adaptation, we tested the effect of the unspecific dopamine antagonist haloperidol and of the specific dopamine Dl receptor antagonists SCH 23390 and SKF 83566-biotinyl in behavioral wavelength discrimination experiments. After injection of dopamine antagonists into the vitreous, a reduction in wavelength discrimination was observed in the range between 560 nm and 630 nm but not in the range between 404 nm and 501 nm.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 |