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RESEARCH PRODUCT
ChemInform Abstract: Tandem Cross Enyne Metathesis (CEYM)-Intramolecular Diels-Alder Reaction (IMDAR). An Easy Entry to Linear Bicyclic Scaffolds.
Carlos Del PozoJavier MiróFernando RabasaAlvaro SanzMaría Sánchez-rosellóSantos Fusterosubject
Olefin fiberTandemBicyclic moleculeChemistryIntramolecular forceSalt metathesis reactionGeneral MedicineConjugated systemEnyne metathesisCombinatorial chemistryDiels–Alder reactiondescription
A new tandem cross enyne metathesis (CEYM)–intramolecular Diels–Alder reaction (IMDAR) has been carried out. It involves conjugated ketones, esters or amides bearing a remote olefin and aromatic alkynes as the starting materials. The overall process enables the preparation of a small family of linear bicyclic scaffolds in a very simple manner with moderate to good levels of diastereoselectivity. This methodology constitutes one of the few examples that employ olefins differently than ethylene in tandem CEYM–IMDAR protocols.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-01 | ChemInform |