Ogļskābes anhidrāžu strukturālie pētījumi jaunu inhibitoru dizainam

6533b828fe1ef96bd1287d99

RESEARCH PRODUCT

Ogļskābes anhidrāžu strukturālie pētījumi jaunu inhibitoru dizainam

Jānis Leitāns

subject

description

Darba mērķis bija ar proteīnu rentgenstruktūranalīzes palīdzību noskaidrot trīsdimensionālās struktūras Latvijas Organiskā sintēzes institūta pētnieku sintezētajiem savienojumiem kompleksā ar ogļskābes anhidrāzēm II un IX (CA II un CA IX) , tādejādi un paverot ceļu jaunu, izoformu specifisku inhibitoru dizainam. Bakalaura darba laikā tika iegūts E.coli producēts šķīstošs un aktīvs CA IX, kā arī izveidots CA IX aktīvā centra mimētiķis un iegūta tā kristālstruktūra. Tika iegūtas arī CA II kristālstruktūras kompleksā ar pieciem jauniem inhibitoriem. Bakalaura darbs izstrādāts Latvijas Biomedicīnas pētījumu un studiju centrā, proteīnu kristalogrāfijas laboratorijā Dr. biol. Kaspara Tāra vadībā. Atslēgvārdi: ogļskābes anhidrāze, CA II, CA IX, proteīnu kristalizācija, racionālais zāļu dizains, proteīnu rentgenstruktūranalīze.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/24930

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
  - PE2_12Optics, non-linear optics and nano-optics
  - PE2_13Quantum optics and quantum information
  - PE2_15Thermodynamics
- PE1Mathematics
  - PE1_1Logic and foundations
  - PE1_6Geometry and global analysis
  - PE1_8Analysis
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  - PE1_11Theoretical aspects of partial differential equations
  - PE1_13Probability
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  - PE1_15Generic statistical methodology and modelling
  - PE1_4 Algebraic and complex geometry
  - PE1_19Scientific computing and data processing
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  - PE3_2Mechanical and acoustical properties of condensed matter, lattice dynamics
  - PE3_3Transport properties of condensed matter
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  - PE3_6Macroscopic quantum phenomena, e.g. superconductivity, superfluidity, quantum Hall effect
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  - PE6_13Bioinformatics, bio-inspired computing, and natural computing
  - PE6_14Quantum computing (formal methods, algorithms and other computer science aspects)
  - PE6_1Computer architecture, embedded systems, operating systems
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  - PE7_7Signal processing
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- PE9Universe Sciences
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  - PE10_18Cryosphere, dynamics of snow and ice cover, sea ice, permafrosts and ice sheets
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  - PE10_13Physical geography, geomorphology
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  - PE11_6Engineering of carbon materials
  - PE11_7Engineering of metal oxides
  - PE11_8Engineering of alternative established or emergent materials
  - PE11_9Nanomaterials engineering, e.g. nanoparticles, nanoporous materials, 1D & 2D nanomaterials
  - PE11_10Soft materials engineering, e.g. gels, foams, colloids
  - PE11_11Porous materials engineering, e.g. covalent-organic, metal-organic, porous aromatic frameworks
  - PE11_12Semi-conducting and magnetic materials engineering
  - PE11_13Metamaterials engineering
  - PE11_14Computational methods for materials engineering
LSLife Sciences
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  - LS1_5Lipid biology
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  - LS1_11Chemical biology
  - LS1_12Protein design
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  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
  - LS1_10Synthetic biology
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  - LS1_9Molecular mechanisms of signalling processes
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- LS2Integrative Biology: from Genes and Genomes to Systems
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  - LS2_2Gene editing
  - LS2_4Gene regulation
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  - LS2_8Proteomics
  - LS2_9Metabolomics
  - LS2_10Glycomics/Lipidomics
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  - LS2_12Biostatistics
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- LS4Physiology in Health, Disease and Ageing
  - LS4_1Organ and tissue physiology and pathophysiology
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- LS3Cell Biology, Development, Stem Cells and Regeneration
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- LS5Neuroscience and Disorders of the Nervous System
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- LS9Biotechnology and Biosystems Engineering
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  - LS9_1Bioengineering for synthetic and chemical biology
SHSocial Sciences and Humanities
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