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RESEARCH PRODUCT
Biological Activity of Flavonoids Copper Complexes
Gloria AlzuetJoaquín BorrásJosé Luis García-jiménezBenigno MacíasMarta González-álvarezsubject
chemistry.chemical_classificationReactive oxygen speciesReducing agentDNA damageRadicalFlavonoidchemistry.chemical_elementPhotochemistryCopperlaw.inventionInorganic Chemistrychemistry.chemical_compoundMenadionechemistrylawPolymer chemistryElectron paramagnetic resonancedescription
Three flavonoid copper(II) complexes Cu2(quercetin)(CH3COO)3(CH3OH) (1), Cu(anthrarufin)(CH3COO)·1/2H2O (2) and Cu(naringin)(OCH3)(CH3OH)2 (3) have been synthesized and characterized by elemental analysis, IR, electronic absorption and EPR (X-band) spectroscopy. The complexes have a strong protective action over the Δsod1 mutant of S. cerevisiae against reactive oxygen radicals generated by an external source of free radicals (H2O2 or the superoxide-generating, menadione). On the other hand, the complexes cleave DNA efficiently even in the absence of reducing agents. The main reactive oxygen species responsible for the DNA strand cleavage have been determined using radical scavengers. A probably mechanism of the DNA damage is proposed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-08-01 | Zeitschrift für anorganische und allgemeine Chemie |