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RESEARCH PRODUCT
The Hammerhead Ribozyme: A Long History for a Short RNA
Marcos De La PeñaInmaculada García-roblesAmelia Cerverasubject
Models Molecular0301 basic medicineHammerhead ribozymephosphodiester bondPharmaceutical ScienceReviewHistory 21st CenturyGenomeAnalytical ChemistryRNA Motifslcsh:QD241-44103 medical and health scienceslcsh:Organic chemistryCircular RNACatalytic DomainDrug DiscoveryAnimalsRNA CatalyticPhysical and Theoretical ChemistryBase PairingLigase ribozymeGeneticsRNA catalysisBase SequencebiologyHydrolysisOrganic ChemistryRibozymeRNARNA CircularSchistosoma mansoniHistory 20th CenturyPlantsbiology.organism_classification030104 developmental biologyChemistry (miscellaneous)Biocatalysisbiology.proteinNucleic Acid ConformationRNAMolecular Medicineself-cleavingMammalian CPEB3 ribozymedescription
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner. The hammerhead ribozyme was the first reported and the most extensively studied member of this family. However, and despite intense biochemical and structural research for three decades since its discovery, the history of this model ribozyme seems to be far from finished. The hammerhead ribozyme has been regarded as a biological oddity typical of small circular RNA pathogens of plants. More recently, numerous and new variations of this ribozyme have been found to inhabit the genomes of organisms from all life kingdoms, although their precise biological functions are not yet well understood.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-04 | Molecules |