Uz retrotranspozonu pamata izveidotu ģenētisko marķieru raksturošana un lokalizācija cilvēka genomā

6533b828fe1ef96bd128881b

RESEARCH PRODUCT

Uz retrotranspozonu pamata izveidotu ģenētisko marķieru raksturošana un lokalizācija cilvēka genomā

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Pētījums veltīts retrotranspozonu marķiera iPBS 2098 raksturošanai. Iepriekš strādājot ar šo praimeri, konkrētā genoma vietā novēroja amplifikācijas rezultātu atšķirības starp juvenīlā idiopātiskā artrīta (JIA), kontroles grupas DNS paraugiem, kurus tālāk klonēja. Šajā pētījumā raksturoja klona a10 sekvenci, lokalizēja to genomā, genotipēja JIA, kontroles grupas paraugos. Klona a10 sekvencē bioinformātiski identificēja 10 polimorfismus. SNP rs188028688 G→A lokalizēja iPBS praimera sekvencē, tāpēc pieņēma, ka šis SNP nosaka produktu esamību. Izmantojot alēles specifisko PĶR, SNP genotipēja 16 JIA, 15 kontroles grupas paraugus. G alēli atrada visos paraugos, taču A alēlei dati bija neskaidri. Amplifikācijas produktus sekvencēja, rezultāti viennozīmīgi liecināja par G alēles esamību. Tādējādi Latvijas populācijā šī A alēle ir minora.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/27873

PEPhysical Sciences and Engineering
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