Hidroksikarbonskābes receptoru (HCAR) ligandu ietekme uz adipoģenēzi un iekaisuma procesiem cilvēka adipocītos un makrofāgos

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RESEARCH PRODUCT

Hidroksikarbonskābes receptoru (HCAR) ligandu ietekme uz adipoģenēzi un iekaisuma procesiem cilvēka adipocītos un makrofāgos

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description

Aptaukošanās un ar to saistītās slimības pēdējā laikā ir pieaugoša problēma Rietumvalstīs, tādēļ plaši tiek pētīti procesi taukaudos. Darba mērķis bija noskaidrot hidroksikarbonskābes (HCA) receptoru ligandu ietekmi uz adipoģenēzi un iekaisuma procesiem, kā arī to ietekmi uz HCA receptoru gēnu ekspresiju cilvēka adipocītos un makrofāgos. Rezultāti liecina, ka neviens no HCA1-3 receptoru ligandiem neietekmē ne adipoģenēzei raksturīgo transkripcijas faktoru, ne pašu HCA receptoru gēnu ekspresiju SGBS adipocītos un diferencētās adipozo audu cilmes šūnās. Savukārt HCA2 un HCA3 receptoru ligandi samazina LPS paaugstināto iekaisuma citokīnu gēnu ekspresiju SGBS adipocītos un THP-1 makrofāgos.

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/20955

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