Ģenētisko faktoru asociācija ar Helicobacter pylori seroloģisko prevalenci Latvijas populācijā

6533b828fe1ef96bd12888a0

RESEARCH PRODUCT

Ģenētisko faktoru asociācija ar Helicobacter pylori seroloģisko prevalenci Latvijas populācijā

subject

TLR10 SNP PCLO Helicobacter pylori (HP)atrofija Bioloģija

description

Baktērija Helicobacter pylori (HP) izraisa hronisku gastrītu, peptisko čūlu, kuņģa adenokarcinomu, MALT limfomu, un tās radītā infekcija ir visplašāk izplatītā cilvēku infekcija. Populācijas pētījumā atklāts, ka HP prevalence Latvijā ir gandrīz 80%, kas ir augsta. Pamatojoties uz Nīderlandes GWAS pētījumu rezultātiem, tika izvēlēti 5 gēni un to polimorfismi- PCLO (rs147900026), TLR10 (rs12233670), FCGR3A (rs147174426), TLE4 (rs138776142), ADRA1D (rs6107461)- lai noskaidrotu, vai šie polimorfismi asociējas ar HP seroprevalenci un kuņģa gļotādas atrofiju Latvijas populācijā. Rezultāti: PCLO gēna rs147900026 G alēle samazina HP infekcijas risku, FCGR3A gēna rs147174426 T alēle tiek būtiski asociēta ar kuņģa gļotādas atrofijas attīstības risku HP- indivīdiem un TLR10 gēna rs12233670 protektīvā T alēle vairāk raksturīga paraugkopai ar pepsinogēna attiecību PgI/PgII>2. Secinājumi: Starp pētāmajiem polimorfismiem, rs147900026, rs147174426, rs12233670 var būt nozīme HP infekcijas un smagas kuņģa gļotādas atrofijas patoģenēzē.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30269

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