6533b828fe1ef96bd1288d58

RESEARCH PRODUCT

The preparation of (14C) and [3H] labelled benzene oxide

Franz OeschKarl L. Platt

subject

Tritiated waterOrganic ChemistryInorganic chemistryOxideHalogenationBiochemistryDecompositionAnalytical Chemistrychemistry.chemical_compoundchemistryDrug DiscoveryOrganic chemistryRadiology Nuclear Medicine and imagingCarbon-14Specific activityTritiumBenzeneSpectroscopy

description

Benzene oxide -[U-14C] was prepared from benzene -(U-14C) by modifications of methods described for the inactive compound. Benzene oxide-[3.6–3H] was prepared by decomposition of 3.6-bis-trimethylsilyl-1,4-cyclohexadiene with tritiated water. bromination of the 1,4-cyclohexadiene-[3,6-3H] so obtained. epoxidation and dehydrobromination. With the latter method benzene oxide-[3,6–3H] can be prepared at a much lower cost and higher specific activity than benzene oxide-[U-14C].

https://doi.org/10.1002/jlcr.2580130403