6533b828fe1ef96bd12890e3
RESEARCH PRODUCT
Modeling methods for studying post-translational and transcriptional modifying enzymes.
Maite RocaVicent MolinerIñaki TuñónJuan Arandasubject
Models MolecularChemistryProcess (engineering)Computational BiologyProteinsNanotechnologyBiochemistryAnalytical ChemistryPost translationalModelling methodsAnimalsHumansBiochemical engineeringProtein Processing Post-Translationaldescription
Biological catalysis is a complex chemical process that involves not only electronic reorganization in the substrate but also the reorganization of the catalyst. This complexity is even larger in the case of post-transcriptional and post-translational modifications which may involve the interaction between two biomacromolecules. However, the development over the past decades of new computational methods and strategies is offering a detailed molecular picture of the catalytic event and a deep understanding of the mechanisms of chemical reactions in biological environments. Here we review the efforts made in the last years to model catalysis in post-transcriptional and post-translational processes. We stress on the advantages and problems of the different computational strategies and their applicability in different cases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-12-01 | Current opinion in chemical biology |