6533b828fe1ef96bd1289416

RESEARCH PRODUCT

Synthesis and antioproliferative activity of new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine

Benedetta MaggioDemetrio RaffaMaria Valeria RaimondiFabiana PlesciaMaria Grazia CusimanoDomenico SchillaciGabriella CancemiStella Maria CascioferroGiuseppe Daidone

subject

Policyclic system 57:713-dimethanopyrazolo[34-b]pyrazolo[3'.4':23]azepino[45-f]azocine antiproliferative activity apoptosisSettore BIO/19 - Microbiologia GeneraleSettore CHIM/08 - Chimica Farmaceutica

description

By reacting methylaminopyrazoles with hexane-2,5-dione in 1,4-dioxane in the presence of p-toluensulfonic acid, new derivatives containing the policyclic sistem 5,7:7,13-dimethanopyrazolo[3,4-b]pyrazolo[3'.4':2,3]azepino[4,5-f]azocine were obtained. The new synthesized compounds were tested preliminarly at 10 microM against five human cancer cell lines showing a range of inhibition of 20-62% against the most susceptible cell lines K562 and HCT116.

yearjournalcountryeditionlanguage
2012-01-01
http://hdl.handle.net/10447/78181