6533b828fe1ef96bd128957e
RESEARCH PRODUCT
Modulation of adrenergic responses of human vas deferens by K+ channel inhibitors
Pascual Medina BessóGloria Vicenta Segarra IrlesMaría Dolores Mauricio AviñóJosé María Vila SalinasPascual Chuan NuezSalvador Lluch Lópezsubject
FarmacologiaUrologiarespiratory systemPatologiadescription
The results suggest that charybdotoxin-sensitive, but iberiotoxin-insensitive, K+ channels are activated by stimulation with norepinephrine and electrical field stimulation to counteract the adrenergic-induced contractions of human vas deferens. Thus, inhibition of these channels increases significantly the contraction, an effect that appears to be mediated by an increase in Ca2+ entry through L-type voltage-dependent Ca2+ channels.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |