6533b829fe1ef96bd1289803
RESEARCH PRODUCT
An efficient β-turn directed cyclization of simple peptidomimetics
Francisco AdriánJuan F. MiravetEnrique García-españaSantiago V. LuisM. I. BurgueteManel Querolsubject
Molecular dynamicsChain (algebraic topology)PeptidomimeticChemistryStereochemistrySimple (abstract algebra)Organic ChemistryDrug DiscoveryBiochemistryCombinatorial chemistrydescription
Abstract Chiral polyaza[n]para- and metacyclophanes are easily assembled starting from the appropriate bis(bromomethyl)arene and diamides obtained from aminoacids and alkylidenediamines. The corresponding ortho-derivatives could not be obtained. Molecular dynamics calculations suggest that those results can be explained through the participation of a β-turn like structure in the open chain intermediate, which is only important for para- and meta-derivatives.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-01-01 | Tetrahedron Letters |