6533b829fe1ef96bd12898ee
RESEARCH PRODUCT
Inhibition of nitric oxide synthase influences the activity of striatal neurons in the rat
Vittorio La GruttaGiuseppe FerraroGiuseppe Di GiovanniS. GalatiPierangelo Sardosubject
Malemedicine.medical_specialtyIndazolesAction PotentialsNerve Tissue ProteinsNitric Oxide Synthase Type IStriatumNeurotransmissionBiologyNitric OxideInhibitory postsynaptic potentialTonic (physiology)Nitric oxidechemistry.chemical_compoundInternal medicineBasal gangliamedicineAnimalsEnzyme InhibitorsRats WistarGeneral NeuroscienceCorpus StriatumRatsElectrophysiologyNitric oxide synthaseElectrophysiologyEndocrinologynervous systemchemistrybiology.proteinNitric Oxide SynthaseNeurosciencedescription
The activity of single units in the striatum of urethane-anesthetized rats was recorded before and after the systemic administration of 7-nitro-indazole (7-NI; 50 mg/kg intraperitoneally), a selective inhibitor of neuronal nitric oxide (NO) synthase. Two neuronal types were clearly distinguishable electrophysiologically, on the basis of either discharge frequency pattern or features of the individual spike waveform (spike duration, negative phase/total duration ratio, and negative phase/total amplitude ratio). Only sporadically discharging neurons (basal firing rate, <0.1 spikes/s) were influenced by 7-NI, which caused a statistically significant increase in their firing rate. In contrast, the activity of continuously discharging neurons (basal firing rate, 4-6 spikes/s) was not affected. We hypothesize that NO neurotransmission could exert a tonic inhibitory influence upon sporadically discharging striatal neurons, which are presumably striatal output neurons.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-06-05 | Neuroscience Letters |