6533b829fe1ef96bd1289962
RESEARCH PRODUCT
Inhibitors acting on nucleic acid synthesis in an oncogenic RNA virus.
Rudolf K. ZahnHans J. SeidelWerner E.g. Müllersubject
DNA polymerasevirusesRNA-dependent RNA polymeraseRauscher VirusGeneral Biochemistry Genetics and Molecular BiologyHistoneschemistry.chemical_compoundMiceRNA polymeraseSense (molecular biology)AnimalsProtaminesPolymerasebiologyHeparinDaunorubicinRNARNA virusCongo RedGeneral Medicinebiology.organism_classificationMolecular biologyPhenanthridineschemistryBiochemistryDNA NucleotidyltransferasesDNA Viralbiology.proteinDactinomycinAcridinesRNA ViralDNAOlivomycinsdescription
IN infection with an oncogenic RNA virus, synthesis of viral RNA seems to be catalysed by an RNA dependent DNA polymerase in the host cell1–4. Several specific inhibitors of viral DNA polymerases have been found5–7 and Spiegelman8 has shown that the activity of viral enzymes depends strongly on the chemical composition of the template. We report here first a new highly specific poison of the Rauscher murine leukaemia virus (RMLV) DNA polymerases; second, several inactivators of the RNA and DNA template involved in the RMLV enzyme systems; and third, the action of actinomycin D on viral DNA polymerases and on host DNA/RNA polymerase. The results are discussed with respect to the influence of actinomycin D on virus multiplication.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1971-08-04 | Nature: New biology |