6533b829fe1ef96bd128998c
RESEARCH PRODUCT
Novel 2-pyrone synthesis via Michael addition of mandelic acid enolate to trans-1,2-diaroylethenes
Santiago BarrosoGonzalo BlayJosé R. PedroIsabel Fernándezsubject
chemistry.chemical_compoundchemistry2-PyroneYield (chemistry)FuranOrganic ChemistryDrug DiscoveryMichael reactionOrganic chemistryGeneral MedicineMandelic acidBiochemistrydescription
4-Aroyl-6-aryl-3-phenyl-2-pyrones are prepared in a three-step procedure involving the Michael addition of a cis-2,5-disubstituted-1,3-dioxolan-4-one, derived from mandelic acid, to trans-1,2-diaroylethenes, cyclisation to a furan under acidic conditions and lactonisation. The 2-pyrones can be also obtained directly from the Michael products under prolonged or strong acidic treatment with little decrease in yield.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-02-15 | Tetrahedron Letters |