A synthetic approach to new polycyclic ring system of biological interest through domino reaction: indolo[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine

6533b829fe1ef96bd1289a5f

RESEARCH PRODUCT

A synthetic approach to new polycyclic ring system of biological interest through domino reaction: indolo[2,3-e][1,2,3]triazolo[1,5-a]pyrimidine

Alessandra Montalbano Chiara Patella Girolamo Cirrincione Gaetano Dattolo Antonino Lauria Patrizia Diana Anna Maria Almerico Paola Barraja

subject

Indolo-triazolo-pyrimidine chemistry.chemical_compound Acetonitriles Pyrimidine chemistry Cascade reaction Docking (molecular)Stereochemistry Organic Chemistry Drug Discovery Domino reaction Biochemistry Docking

description

Abstract The title indolo-triazolo-pyrimidines were obtained from 3-azidoindoles and can be used as models for the design of DNA-interactive compounds. Hetero-domino reaction of azidoindoles/pyrroles and acetonitriles constitutes the synthetic entry to annelated 1,2,3-triazolo[1,5- a ]pyrimidines.

year	journal	country	edition	language
2006-03-01	Tetrahedron Letters

https://doi.org/10.1016/j.tetlet.2006.01.112

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