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RESEARCH PRODUCT
A Radical Signal Activates the Epigenetic Regulation of Longevity
Mario G. MirisolaMario G. MirisolaValter D. Longosubject
chemistry.chemical_classificationGeneticsReactive oxygen speciesbiologyPhysiologyChromatin bindingmedia_common.quotation_subjectHormesisLongevityCell BiologySubtelomereHistonechemistrybiology.proteinDemethylaseEpigeneticsMolecular Biologymedia_commondescription
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-06-01 | Cell Metabolism |