6533b829fe1ef96bd1289ae8

RESEARCH PRODUCT

The clinical benefit of instituting a prospective clinical community-acquired respiratory virus surveillance program in allogeneic hematopoietic stem cell transplantation

Carla AznarDavid NavarroIgnacio LorenzoJosé Luis PiñanaAitana Balaguer-rosellóEva María González-barberáManuel GuerreiroJuan MontoroCarlos CarreteroRosa SanzMiguel SalavertMiguel A. SanzJaime SanzMaría Dolores GómezGuillermo Sanz

subject

Prospective respiratory virus surveillance program0301 basic medicineMicrobiology (medical)medicine.medical_specialtymedicine.medical_treatment030106 microbiologyHematopoietic stem cell transplantationRespiratory syncytial virusArticleParainfluenza virus03 medical and health sciences0302 clinical medicineStudy reportCommunity-acquired respiratory virusInternal medicinemedicineHumansProspective Studies030212 general & internal medicineStage (cooking)Prospective cohort studyRespiratory Tract InfectionsRetrospective Studiesbusiness.industryHematopoietic Stem Cell TransplantationRetrospective cohort studyInfluenzaInfectious Diseasesmedicine.anatomical_structureRespiratory virus infectionVirusesAllogeneic hematopoietic stem cell transplantationRespiratory virusbusinessLower mortalityImmunodeficiency score indexRespiratory tract

description

Highlights • Rapid detection methods used as first diagnostic test for CARVs may delayed the start of antiviral therapy in a significant number of influenza and RSV cases. • Syndromic multiplex RT-PCR-based prospective clinical CARV survey in allo-HCT recipients translates into a lower mortality rate as compared to standard clinical practice based on RSV and influenza virus rapid detection test. • We found that donor/recipient HLA mismatch, CARV LRTD and high-risk ISI were also associated with higher mortality.

yearjournalcountryeditionlanguage
2019-09-25Journal of Infection
https://doi.org/10.1016/j.jinf.2019.12.022