6533b829fe1ef96bd128a49f
RESEARCH PRODUCT
Acid–base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids
José M. LlinaresAlejandra Sornosa-tenAna BudimirM. Teresa AlbeldaIvo PiantanidaEnrique García-españaJuan C. Fríassubject
tripodal polyamines; DNA and RNA interactions; RNA selectivity; nucleotidesMagnetic Resonance SpectroscopyStereochemistryProtonation010402 general chemistry01 natural sciencesBiochemistrychemistry.chemical_compoundNucleic AcidsPolyaminesImidazoleNucleotidePhysical and Theoretical Chemistrychemistry.chemical_classificationMolecular StructureNucleotides010405 organic chemistryOrganic ChemistryWaterRNANuclear magnetic resonance spectroscopyHydrogen-Ion Concentration0104 chemical sciencesSolutionsChemistrychemistryNucleic acidThermodynamicsProtonsSelectivityDNAdescription
Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-05-21 | Organic & Biomolecular Chemistry |