6533b829fe1ef96bd128a602

RESEARCH PRODUCT

Unveiling Bacterial Interactions through Multidimensional Scaling and Dynamics Modeling

Carlos Peña GarayCristina VilanovaJose Manuel MartíPedro Dorado-moralesManuel Porcar

subject

MultidisciplinaryBacteriaComputer scienceMicrobial Consortiafood and beveragesIdentification (biology)Data miningMultidimensional scalingcomputer.software_genreModels BiologicalcomputerArticle

description

AbstractWe propose a new strategy to identify and visualize bacterial consortia by conducting replicated culturing of environmental samples coupled with high-throughput sequencing and multidimensional scaling analysis, followed by identification of bacteria-bacteria correlations and interactions. We conducted a proof of concept assay with pine-tree resin-based media in ten replicates, which allowed detecting and visualizing dynamical bacterial associations in the form of statistically significant and yet biologically relevant bacterial consortia.

https://doi.org/10.1038/srep18396