Vidējās cerebrālās artērijas oklūzijas ietekme uz peļu mitohondriju funkcionalitāti

6533b829fe1ef96bd128a768

RESEARCH PRODUCT

Vidējās cerebrālās artērijas oklūzijas ietekme uz peļu mitohondriju funkcionalitāti

Ksenija Lūcija Bahire

subject

mitohondriji smadzeņu garoza Farmācija respirometrija peles išēmisks insults

description

Mitohondriji ir atbildīgi par šūnu enerģijas ražošanu oksidatīvās fosforilācijas ceļā. Išēmisks insults izsauc patoloģiskas izmaiņas šūnu funkcionēšanā, it īpaši šūnu organellu darbībā, tai skaitā mitohondriju. Pētījuma mērķis bija izpētīt išēmijas un asinsrites reperfūzijas ietekmi uz insulta skarto un neskarto smadzeņu pusložu mitohondriju funkcijām, veicot filamenta inducētu vidējās cerebrālās artērijas oklūziju pelēm. Iegūtie rezultāti parāda, ka vislielākā atšķirība skābekļa patēriņā starp insulta skarto un neskarto puslodēm un visaugstākā ROS izdalīšanās ir novērojamas uzreiz pēc oklūzijas, bet visbūtiskākais samazinājums mitohondriālā elpošanā novērojams 2 stundas pēc reperfūzijas insulta skartā puslodē. Iegūtie rezultāti sniedz jaunas zināšanas par mitohondriju funkcionēšanu abās smadzeņu puslodēs pēc išēmiska insulta bojājumiem.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54709

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