Bakteriofāga AP205 apvalka proteīna strukturālie pētījumi

6533b829fe1ef96bd128a7dc

RESEARCH PRODUCT

Bakteriofāga AP205 apvalka proteīna strukturālie pētījumi

subject

dimēri ssRNA fāgs AP205 Bioloģija proteīnu struktūra apvalka proteīns

description

Darbā ar rentgenstruktūranalīzes palīdzību tika noteikta Acinetobacter fāga AP205 apvalka proteīna struktūra 1,9 Å izšķirtspējā. Proteīna vispārējā struktūra ir līdzīga radniecīgo bakteriofāgu iepriekš noteiktajām struktūrām, bet ir vērojamas vairākas būtiskas atšķirības, no kurām nozīmīgākā ir C- un N- galu atrašanās uz kapsīdas virsmas. Iegūtie rezultāti izskaidro AP205 fāga kapsīdu toleranci pret garām insercijām C- un N- galos, kā arī paver ceļu racionālai apvalka proteīna modificēšanai praktiskiem pielietojumiem. Darbs izstrādāts Latvijas Biomedicīnas pētījumu un studiju centra proteīnu kristalogrāfijas laboratorijā Dr. biol. Kaspara Tāra vadībā.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30249

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