ESR Spectra o f Normal Human Serum after Treatment with Complement Activating Agents*

6533b829fe1ef96bd128aed3

RESEARCH PRODUCT

ESR Spectra o f Normal Human Serum after Treatment with Complement Activating Agents*

Melchiorre Brai Antonio Bartolotta Maria Brai Marcello Messina Pietro L. Indovina

subject

Elapid Venoms Male Free Radicals Chemistry Kinetics Electron Spin Resonance Spectroscopy Zymosan Blood Proteins Complement System Proteins General Biochemistry Genetics and Molecular Biology Complement system Complement (complexity)Esr spectra Biochemistry Humans Female Complement Activation After treatment

description

Abstract We describe the appearance of a free-radical signal in the ESR spectrum of normal human serum incubated with several complement activating agents. The intensity of this signal is dependent of dose of activating agents, time and temperature. Signals elicited by different complement activators differ in morphology and kinetics. Inhibition by treatment with EDTA and the presence of the signal in activated C 6-deficient rabbit serum suggest that the con-vertase forming steps of complement activation (C2 to 5) could be the source of free-radical containing molecules.

year	journal	country	edition	language
1980-09-01	Zeitschrift für Naturforschung C

https://doi.org/10.1515/znc-1980-9-1034

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