6533b82afe1ef96bd128b619

RESEARCH PRODUCT

New syntheses of condensed heterocycles from isoxazole derivatives. V. Pyrrolo[3,4-b]pyridin-4-ones

Giuseppe DaidoneEnrico AielloGaetano DattoloSalvatore PlesciaGirolamo Cirrincione

subject

chemistry.chemical_compoundAcetic acidChemistryHydrogenolysisNitrationOrganic ChemistryGrignard reactionOrganic chemistryIsoxazoleIron powder

description

Hydrogenolysis with Raney-Nickel or iron powder in acetic acid of 2,5-diphenyl-4-nitro-3-(3,5-R,R-4-isoxazolyl)pyrrolyl ketones, prepared by the Grignard reaction of 2,5-diphenylpyrrole and 3,5-R,R-4-isoxazolecarboxilic acid chlorides followed by nitration, afforded directly the desired 6H-pyrrolo[3,4-b ]pyridin-4-ones.

yearjournalcountryeditionlanguage
1977-10-01Journal of Heterocyclic Chemistry
https://doi.org/10.1002/jhet.5570140614