Polycondensed nitrogen heterocycles. Part13. Pyrrolo[3,2-b]indole by intramolecular nucleophilic substitution reaction in the pyrrole series

6533b82afe1ef96bd128b644

RESEARCH PRODUCT

Polycondensed nitrogen heterocycles. Part13. Pyrrolo[3,2-b]indole by intramolecular nucleophilic substitution reaction in the pyrrole series

Gaetano Dattolo Anna Maria Almerico Girolamo Cirrincione Enrico Aiello

subject

Indole test Substitution reaction Stereochemistry Organic Chemistry Medicinal chemistry chemistry.chemical_compound Nucleophile chemistry Nucleophilic aromatic substitution Intramolecular force polycyclic compounds Nucleophilic substitution Acid hydrolysis Pyrrole

description

An intramolecular nucleophilic substitution in the pyrrole series has been generalized. The behaviour of nitro, chlorine, bromine and iodine as leaving groups towards the nucleophilic amino group was observed. An acid catalyzed mechanism has been proposed.

year	journal	country	edition	language
1984-05-01	Journal of Heterocyclic Chemistry

https://doi.org/10.1002/jhet.5570210318

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