6533b82afe1ef96bd128b77b
RESEARCH PRODUCT
FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022
Carla RizzoSara AmataIvana PibiriAndrea PaceSilvestre BuscemiAntonio Palumbo Piccionellosubject
Inorganic ChemistryheterocyclesfluorineOrganic ChemistryGeneral MedicineSettore CHIM/06 - Chimica OrganicaPhysical and Theoretical ChemistryMolecular BiologyFDA-approvedSpectroscopyCatalysisComputer Science Applicationsdescription
The inclusion of fluorine atoms or heterocyclic moiety into drug structures represents a recurrent motif in medicinal chemistry. The combination of these two features is constantly appearing in new molecular entities with various biological activities. This is demonstrated by the increasing number of newly synthesized fluorinated heterocyclic compounds among the Food and Drug Administration FDA-approved drugs. In this review, the biological activity, as well as the synthetic aspects, of 33 recently FDA-approved fluorinated heterocyclic drugs from 2016 to 2022 are highlighted.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2023-04-23 |