6533b82afe1ef96bd128bfc3

RESEARCH PRODUCT

ChemInform Abstract: Polycondensed Nitrogen Heterocycles. Part 22. Pyrrolo(3,4-d)-1,2,3-triazines: A New Ring System as Potential Antineoplastic Agent.

Anna Maria AlmericoGirolamo CirrincioneEnrico AielloGaetano Dattolo

subject

chemistryIntramolecular forcechemistry.chemical_elementGeneral MedicineRing (chemistry)Medicinal chemistryNitrogenCoupling reactionD-1

description

Diazotization of the 3-aminopyrrole-4-carboxamides 6a,b under different conditions directly led to the new ring system pyrrolo[3,4-d]-1,2,3-triazine in excellent yields through an intramolecular coupling reaction. In all the cases it was impossible to isolate the intermediate 3-diazopyrroles.

yearjournalcountryeditionlanguage
1990-05-29ChemInform
https://doi.org/10.1002/chin.199022206