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RESEARCH PRODUCT
Development of Rat DC by in Vitro Culture of Bone Marrow Cells
Maria MehligHans-peter DienesKonrad ReskeChristoph Scheichersubject
medicine.anatomical_structurelawPrimary immune responseLow doseLewis ratsRecombinant DNAmedicineCancer researchDendritic cellBone marrowBiologyIn vitrolaw.inventiondescription
Dendritic cells (DC) represent a subpopulation of leukocytes of bone marrow (BM) origin, involved in crucial immunological reactions. DC play a fundamental role in the primary immune response by stimulating quiescent T cells. In this study we describe an in vitro culture system to raise DC from unfractionated bone marrow (BM) cells of LEWIS rats in the presence of low doses of mouse recombinant GM-CSF, that was successfully used in previous work to culture mouse DC1,2,3.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 |