6533b82afe1ef96bd128bff3
RESEARCH PRODUCT
Iron oxide/oleic acid magnetic nanoparticles possessing biologically active choline derivatives
Dmitry ZablotskyMikhail MaiorovAlla ZablotskayaElmars BlumsIzolda Segalsubject
ChemistryIron oxideNanoparticleBiological activity02 engineering and technologyequipment and supplies010402 general chemistry021001 nanoscience & nanotechnologyLigand (biochemistry)Antimicrobial01 natural sciencesCombinatorial chemistry0104 chemical scienceschemistry.chemical_compoundOleic acidMagnetic nanoparticles0210 nano-technologyhuman activitiesSuperparamagnetismdescription
Abstract In recent years, synthetic magnetic nanoparticles have made a major contribution to biomedicine. Interest in iron oxide magnetic nanoparticles conditioned by the fact that they are nontoxic, and possess the unique opportunity to deliver medicines to certain organs by external magnetic field. We have developed a synthetic procedure, which is based on binding of the first biologically active substance with the magnetic core, and subsequent immobilization of another biologically active substance (ligand) on the modified surface of nanoparticles thus creating plasma membrane-like structures. Using the proposed methodology, we have obtained new nontoxic magnetic nanoparticles, functionalized with pre-synthesized aliphatic and heterocyclic choline analogues, and determined their composition, structure, and size by different physicochemical methods. Interaction of the obtained nanoparticles with tumor cells and normal fibroblasts, as well as, bacterial cells and fungi has been evaluated. The resulting magnetic fluids revealed superparamagnetic properties and affected tumor and microbial cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |